• Sarcoidosis

    BOTTOM LINE Sarcoidosis is a systemic inflammatory disorder characterized by noncaseating granulomas classically involving lungs causing a spectrum of disease from asymptomatic hilar adenopathy to progressive interstitial lung disease. Virtually…

  • IgG4-related disease (IgG4-RD)

    BOTTOM LINE IgG4-RD is an immune-mediated fibroinflammatory disorder characterized by inflammatory pseudotumours and/or strictures. Nearly any organ can be involved, but common presentations may include 1) autoimmune pancreatitis with sclerosing…

  • Relapsing Polychondritis (RPC)

    BOTTOM LINE Relapsing polychondritis (RPC) is a rare immune-mediated disease causing inflammation of cartilaginous structures. Manifestations include auricular swelling, scleritis, inflammatory arthritis, nasal chondritis, airway inflammation, and rash. RPC may…

  • Anti-Phospholipid Antibody Syndrome (APS)

    BACKGROUND Antiphospholipid syndrome (APS) is characterized by arterial, venous, or small vessel thromboembolic events and/or pregnancy morbidity with persistent antiphospholipid antibodies (aPL). APS can be primary or secondary to an…